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学 术 报 告


题目 :     化学方法在蛋白质甲基化酶中的应用:机理、功能和小分子抑制
 
报告人: MinKui Luo, Ph.D
              Associate Member & Associate Professor
              Chemical Biology Program
              Memorial Sloan Kettering Cancer Center
 
地  点: 南京大学仙林校区化学化工学院H201蒋雯若报告厅
时 间: 2017年6月22日(周四)上午 10:00
 
邀请人: 赵劲教授
 
Protein methyltransferases (PMTs) are involved in numerous epigenetic processes through histone and nonhistone methylation. The dysregulation of the processes has been implicated in many diseases including developmental abnormalities, neurological disorders and cancer. Among over 50 human protein lysine methyltransferases (PKMTs) and 10 human protein arginine methyltransferases (PRMTs), most of them remain to be fully characterized in regard to their substrate profiles and epigenetic functions. With our long-term goal to know the PMT-related unknown and identify/target druggable PMT-associated processes for cancer therapy, the current ongoing projects in my laboratory mainly focus on the following two aspects: (1) develop and apply novel technologies to profile PMT substrates in the context of accurate cancer models; (2) design and identify potent, target-specific small-molecule PMT inhibitors as pharmacological modulators and anti-cancer reagents. Our ambiguous vision is to build up the technological platforms at the interface between chemistry and biology, and leverage them to profile the targets and inhibitors of all cancer-relevant PMTs.
                            
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