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燕 红,教授
 

Email: hyan1965@nju.edu.cn

Tel: 0086-025-89686724

 

燕红 教授

Prof. Hong Yan

2005-present: Professor, Nanjing University

2004-2005: Research scientist at Nanomat Inc. USA

2000-2004: Research associate in University of Notre Dame, USA

1997-2000: Postdoc in University of Bayreuth, Germany

1996-1997: Postdoc in University of Neuchatel, Switzerland

1993-1996: Lecturer, Nanjing University

1990-1993: Ph.D. student in Inorganic Chemistry, Nanjing University

1983-1990: B.Sc. & M. Sc. student in Inorganic Chemistry, Inner Mongolia University

燕红, 教授、博士生导师。19871990年分别获内蒙古大学化学系无机化学专业学士和硕士学位。19901993年在南京大学配位化学研究所攻读博士学位, 研究方向为生物金属有机化学。 19931996 年任配位化学国家重点实验室讲师,研究核磁共振的方法及应用。 19961997年在瑞士Neuchatel 大学做博士后, 研究方向为金属有机骨架的自组装。19972000年在德国Bayreuth 大学做博士后, 研究过渡金属诱导的惰性键活化。 20002004年在美国Notre Dame做研究助理, 方向为金属硼烷及金属碳硼烷化学。20042005年在美国宾州Nanomat Inc. 从事锂电池的研究。2005年起任南京大学化学化工学院教授、博士生导师,方向为过渡金属诱导的惰性键活化以及金属有机发光体系的研究。

Research Interests

 

Metal-induced B-H activation and functionalization of dicarba-closo-dodecaboranes

Dicarba-closo-dodecaboranes have been used for decades as versatile building blocks for construction of functional materials and pharmaceuticals owing to their useful properties such as thermal stability, unique structures and electronic effects, enriched boron content and low bio-toxicity. However, substitution at boron atoms, in particular, selective boron-functionalization of carborane clusters is still a synthetic challenge because of the chemically close B−H bonds and limited functional groups. This situation seriously restricts further development of applications of carborane derivatives.

Figure 1

Recently we utilized metal-induction to have achieved selective B-H activation at ambient temperature through the introduction of substrates such as alkynes, azido species and azides. And unusual B-functionalized groups such as cyclopentadienyl (Cp), norbornyl and norbornadienyl (Figure 1) have been obtained that are unavailable by conventional methods. The mechanistic studies have been performed by combination of DFT calculations and experimental results.

Carborane tuning photophysical properties

Two-photon absorption (TPA) has attracted considerable attention for the promising applications in two-photon dynamic therapy, optical power limiting materials and bioimaging. We have introduced carboranes into dendritic or star-shaped π-conjugated organic fluorophores, as a result, fluorescence quantum yields were significantly improved and the largest two-photon absorption among the known carborane-based derivatives has been obtained thus the compound was successfully applied in two-photon fluorescence 2D & 3D bioimaging (Figure 2).

Figure 2

On the other hand, owing to the unique 3D pseudo-aromatic geometric structures and push-pull electronic properties, carboranes can considerably change luminescent efficiency and emission wavelengths of traditional iridium complexes. In addition, the effect of o-carborane derivatives on luminescence shows media-dependence both in solution and solid state that is converse to dielectric constant of media. This is attributed to the specific C–C bond of o-carborane in excited state which is strongly affected by its outer surroundings as DFT calculations has shown. The water-soluble nido-o-carborane-functionalized iridium(III) complex (nido-fac-o) has high phosphorescence efficiency and long emission lifetime in aqueous solution, thus has been successfully applied in bioimaging including fluorescence lifetime imaging (Figure 3).

Figure 3

Selected Publications

1.   Variable photophysical properties of iridium(III) complexes triggered by closo- and nido-carborane substitution, Shi, C.; Sun, H. B.; Tang, X.; Lv, W.; Yan, H*.; Zhao, Q*.; Wang, J. X.; Huang, W.* Angew. Chem. Int. Ed. 2013, 52, 13434-13438.

2.   Unprecedented Boron-functionalized Carborane Derivatives by Facile and Selective Cobalt-induced B-H Activation, Z. J. Wang, H. D. Ye, Y. G. Li, Y. Z. Li and H. Yan*, J. Am. Chem. Soc. 2013, 135, 11289-11298.

3.   Carborane-Based Starburst Organic Fluorophores with Enhanced Two-Photon Absorption for Fluorescence Microscopy Imaging, L. Zhu, W. Lv, S. J. Liu, S. L. Li, H. Yan,* Q. Zhao,* W. Huang,* Chem. Commun. 2013, 49, 10638–10640.

4.   Antimicrobial activity of a ferrocene-substituted carborane derivative targeting multidrug-resistant infection, S. H. Li, Z. J. Wang, Y. F. Wei, C. Y. Wu, S. P.  Gao, H. Jiang, X. Q. Zhao, H. Yan, X. M. Wang*, Biomaterials, 2013, 34, 902–911.

5.   Carborane tuning photophysical properties of phosphorescent iridium(III) complexes, C. Shi, H. B. Sun, Q. B. Jiang, Q. Zhao,* J. X. Wang, W. Huang,* and H. Yan*, Chem. Commun. 2013, 49, 4746-4748.

6.   Cobalt-promoted B-H and C-H activation: Facile B-C coupling of carboranedithiolate and cyclopentadieneyl , R. Zhang, L. Zhu, G. F. Liu, H. M. Dai, Z. Z. Lu, J. B. Zhao and H. Yan*, J. Am. Chem. Soc. 2012, 134, 10341–10344.

 



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