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郭子建,教授
 

Email: zguo@nju.edu.cn

Tel: 0086-025-89689006

 

郭子建 教授

Prof. Zijian Guo

1999-present                Professor, Nanjing University

2001-2005                    Cheung Kong Professor, Ministry of Education

1996-1999                    Research Associate, University of Edinburgh, UK

1996-1996                    Visiting Scientist, University of British Columbia, Canada

1994-1996                    Post-doctoral Research Fellow, University of London, Birkbeck College, UK

1989-1994                    PhD Student, University of Padua, Italy

郭子建       教授、博士生导师。1989-1994年在意大利帕多瓦大学并获得博士学位。曾在英国伦敦大学、加拿大不列颠哥伦比亚大学、英国爱丁堡大学从事研究工作,研究方向为抗肿瘤金属配合物的作用机理研究。1999年起担任南京大学教授、博士生导师。1999年获得国家自然科学基金委杰出青年基金资助,2001年被聘为教育部长江学者奖励计划特聘教授,2002年被评为享受国务院特殊津贴专家。目前担任Chem. Soc. Rev., Inorg. Chem., Dalton Trans., J. Biol. Inorg. Chem., J. Inorg. Biochem.等国际期刊的编委以及《中国科学:化学》等多个国内刊物的编委或副主编。主要研究领域为生物无机化学,研究方向包括:无机药物化学、金属-生物大分子相互作用机制以及生物无机物种的荧光识别与检测。

 

Research Interests

Metal-based Antitumor Agents and Artificial Nucleases

Platinum-based anticancer drugs play critical role in the treatment of many different malignancies. However, there is a huge scope in further rational design of these complexes to overcome the side effects, resistance and toxicities which often accompanying the chemotherapy. Metal-based artificial nucleases provide much diverse DNA cleavage abilities and activities, and can be applied in modern biotechnology and medicine. In this context, our research work focuses on the design of metal complexes with novel structural features and reactivities. Transitional metals such as platinum, palladium, nickel, copper and zinc are employed in these studies.

Targeting and delivery (DTD) strategies can be used to prevent the above mentioned shortcomings of platinum-based chemotherapy. Our approaches include conjugation of platinum drugs with selective targeting moieties or encapsulation of platinum drugs in host molecules or particles to achieve enhanced permeability and retention effect in tumour tissues. For example, bis-phosphonates, peptides, proteins and nanoparticles are commonly used in targeting and delivery studies.

Metal-Biomolecule Interactions

Metal complexes excert their biological effects and activities by interacting biomolecules such as DNA and proteins. For example, the anticancer efficacy of platinum anticancer drugs was achieved by their interaction with DNA without being deactivated by cellular proteins. Metal induced b-amyloid aggregations are potentially associated with Alzheimer’s disease, and this why metal chelators can have a role in the therapy of the disease by eliminate excessive causative metals. In these aspects, we have been investigating the role of metals and metal complexes in their DNA and protein interactions and recognitions. These studies are important for the understanding of the mechanism of action of metal-based biological and medicinal agents.

 

Fluorescent Imaging of Biological Inorganic Species

Coordination chemistry plays an essential role in the design of photoluminescent probes for biological inorganic species. Metal coordination-induced alteration or nucleophilic addition of small molecule is essential for the development of fluorescent sensors for these species. related applications in photoluminescent sensing and detection.  We have been recently developed a variety of fluorescent sensors which can be used for the detection of biologically essential metal ions, environmentally toxic heavy metals, inorganic drug species, DNA nucleases, and small signaling inorganic molecules.

 

Selected Publications

1.     Targeting and delivery of platinum-based anticancer drugs, Xiaoyong Wang, Zijian Guo, Chem. Soc. Rev., 2013, 42, 202-224.

2.     A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles, Jinzhuan Wang, Xiaoyong Wang,  Yajie Song, Jing Wang, Changli Zhang, Cunjie Chang, Jun Yan, Lin Qiu, Mingmin Wu, Zijian Guo, Chem. Sci., 2013, 4, 2605–2612.

3.     Specific recognition of DNA depurination by a luminescent terbium(III) complex, Xiaohui Wang, Xiaoyong Wang, Shanshan Cui, Yan Wang,  Guangju Chen, Zijian Guo, Chem. Sci., 2013, 4, 3748–3752.

4.     Inhibitory action of macrocyclic platiniferous chelators on metal-induced A Aggregation, Xiaohui Wang, Xiaoyong Wang, Changli Zhang, Yang Jiao, Zijian Guo, Chem. Sci., 2012, 3, 1304–1312.

5.     A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria, Yuncong Chen, Chengcheng Zhu, Zhenghao Yang, Junjie Chen, Yafeng He, Yyang Jiao, Weijiang He, Lin Qiu, Jiajie Cen, Zijian Guo, Angew. Chem., 2013, 125, 1-5.

6.     Metal coordination in photoluminescent sensing, Zhipeng Liu, W.eijiang He, Zijian Guo, Chem. Soc. Rev., 2013, 42, 1568-1600.

7.     Visible Light Excitable Zn2+ Fluorescent Sensor Derived from an Intramolecular Charge Transfer Fluorophore and Its in Vitro and in Vivo Application, Fan Qian, Changli Zhang, Yuming Zhang, W.eijiang He, Xiang Gao, Ping Hu, Zijian Guo, J. Am. Chem. Soc., 2009, 131, 1460-1468.



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